The Difference Between Methylcobalamin and Cyanocobalamin
Methylcobalamin vs Cyanocobalamin: What’s the Difference?
If you’ve been researching Vitamin B12 supplements or injections, you’ve probably come across two common forms: Methylcobalamin and Cyanocobalamin. While both are forms of Vitamin B12, they’re not exactly the same — and knowing the difference can help you make a better decision for your health.
What Is Methylcobalamin?
Methylcobalamin is the active, bioavailable form of Vitamin B12. That means your body can use it immediately, without needing to convert it. It’s naturally found in food sources like fish, meat, and dairy — and is especially known for supporting the nervous system and energy levels.
What Is Cyanocobalamin?
Cyanocobalamin is a synthetic version of B12 that the body must convert into a usable form (either methylcobalamin or adenosylcobalamin). It’s often used in low-cost supplements and fortified foods because it’s stable and inexpensive to produce.
Key Differences
- Bioavailability: Methylcobalamin is immediately usable by the body, while Cyanocobalamin needs conversion.
- Natural vs Synthetic: Methylcobalamin is found naturally in foods, whereas Cyanocobalamin is lab-made.
- Effectiveness: Methylcobalamin may be better for supporting nerve health and treating deficiencies, especially in people with absorption issues.
- Stability: Cyanocobalamin is more shelf-stable but may contain trace amounts of cyanide (in extremely low, non-toxic doses).
When to Choose Methylcobalamin
If you’re looking for faster absorption, better neurological support, or you have a known deficiency, Methylcobalamin is generally the preferred choice — especially when taken through injections. It’s also a better option for people with MTHFR gene mutations, who may struggle to convert B12 efficiently.
Which Is Right for You?
Both forms can increase B12 levels, but the delivery method and your body’s ability to absorb the vitamin matter. Speak to a healthcare provider about the most suitable form based on your symptoms, health status, and goals.
To dive deeper into the science behind Vitamin B12 types, check out this NCBI research article.